I started using this on my very arthritic 13yr old GSD just over 2 weeks ago under advice from a vet nurse based off his age. He's got more bounce in his step when out on walks and sleeps more soundly on the sofa and in his bed. I was initially skeptical that this would do anything, but I have to admit that I'm somewhat impressed taking the holistic approach is actually helping him. I bought a second 50ml bottle and will continue taking this approach with him, I agree with the nurse that this is a much kinder approach than Loxicom/Metacam which can cause damaging effects to Liver in an already ageing dog who has lived to the longest expectancy the breed predicts.